易游娱乐

2007.09 - 2013.07 北京大学，前沿交叉学科研究院，博士

2002.09 - 2006.07 南昌大学，生命科学学院，学士

2018.07 -2023.06 耶鲁大学，分子生物物理学与生物化学系，研究科学家

2014.07 -2018.07 耶鲁大学，细胞生物学系，博士后

核酸与蛋白质纳米装置设计与组装;

DNA纳米仿生核孔的构建;

DNA纳米递送通道设计与应用.

国家重点研发计划重点专项，2025-2029，参与

国家自然科学基金面上项目，2025-2029，主持

国家海外高层次引进人才计划，2024-2026，主持

22.      Q. Feng, M. Saladin, C. Wu, E. Cao, W. Zheng, A. Zhang, P. Bhardwaj, X. Li, Q. Shen, L. E Kapinos, T. Kozai, M. Mariappan, C. Lusk, Y. Xiong, R. YH Lim, C. Lin. "Channel width modulates the permeability of DNA origami–based nuclear pore mimics", Sci Adv, 2024, 10, eadq8773.

21.      Q. Shen, Q. Feng, Q. Xiong, C. Wu, Y. Yuan, T. Tian, S. Yuan, J. Temple, C. Aiken, A.N. Engelman, C.P. Lusk, C. Lin, and Y. Xiong, "Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels", Nature Structural & Molecular Biology, 2023, 30, 425-435.

20.      Q. Shen, S. Kumari, C. Xu, S. Jang, J. Shi, R.C. Burdick, L. Levintov, Q. Xiong, C. Wu, S.C. Devarkar, T. Tian, T.N. Therese, Y. Hu, S. Yuan, J. Temple, Q. Feng, P. Lusk, C. Aiken, A.N. Engelman, J. Perilla, V.K. Pathak, C. Lin, and Y. Xiong, "The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores", Proc Natl Acad Sci USA, 2023, 120, e2202815120.

19.      Q. Shen^#, Q. Xiong^#, K. Zhou, Q. Feng, L. Liu, T. Tian, C. Wu, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity", J Am Chem Soc, 2023, 145, 1292–1300.

18.      P. Zhan, A. Peil, Q. Jiang, D. Wang, S. Mousavi, Q. Xiong, Q. Shen, Y. Shang, B. Ding, C. Lin, Y. Ke, and N. Liu. "Recent Advances in DNA Origami-Engineered Nanomaterials and Applications", Chem Rev, 2023, 123, 3976-4050.

17.      W. Luo, V. Demidov, Q. Shen, H. Girão, M. Chakraborty, A. Maiorov, F. Ataullakhanov, C. Lin, H. Maiato, E. Grishchuk. "CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide-state sensitive manner", Sci Adv, 2023, 9, eabq5404.

16.      Q. Shen, C. Wu, C. Freniere, T. N. Tripler, Y. Xiong. "Nuclear Import of HIV-1", Viruses, 2021, 13, 2242.

15.      Q. Shen, T. Tian, Q. Xiong, P.D.E. Fisher, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins", J Am Chem Soc, 2021, 143, 12294-12303. Faculty Opinions recommended.

14.      Q. Shen and C. Lin. "RNA returns to the fold", Nature Chemistry, 2020, 12, 221-222.

13.  S. Yuan, L Peng, J. J. Park, Y. Hu, S. C. Devarkar, M. B. Dong, Q. Shen, S. Wu, S. Chen, I. B. Lomakin, and Y. Xiong. "Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA", Mol Cell, 2020, 80, 1-12.

12.  J. Temple^#, T.N. Tripler^#, Q. Shen^#, Y. Xiong. "A snapshot of HIV-1 capsid–host interactions", Curr Res Struct Biol, 2020, 2, 222-228.

11.  Q. Shen, M.W. Grome, Y. Yang, and C. Lin. "Engineering Lipid Membranes with Programmable DNA Nanostructures", Adv Biosyst, 2020, 4, 1900215.

10.  Q. Xiong, C. Xie, Z. Zhang, L. Liu, J. Powell, Q. Shen, and C. Lin, "DNA Origami Post-Processing by CRISPR-Cas12a", Angew Chem Int. Edit, 2020, 59, 3956-3960.

9.  Y. Hu, K. Knecht, Q. Shen, Y. Xiong, "Multifaceted HIV-1 Vif interactions with Human E3 Ubiquitin Ligase and APOBEC3s". FEBS J., 2020, 288, 3407-3417.

8.  G. Stanley, B. Akpinar, Q. Shen, PDE. Fisher, C.P. Lusk, C. Lin, and B. Hoogenboom, "Quantification of Biomolecular Dynamics Inside Real and Synthetic Nuclear Pore Complexes Using Time-Resolved Atomic Force Microscopy", ACS Nano, 2019, 13, 7949-7956.

7.  P. Fisher^#, Q. Shen^#, B. Akpinar, L. Davis, K. Chung, D. Baddeley, A. Šarić, T. Melia, B. Hoogenboom, C. Lin, and P. Lusk. "A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement", ACS Nano, 2018, 2, 1508-1518. (co-first author position determined by coin toss)

6.  X. Deng, X. Zhang, B. Tang, H. Liu, Q. Shen, Y. Liu, and L. Lai. "Design, Synthesis, and Evaluation of Dihydrobenzo indole-6-sulfonamide as TNF-α Inhibitors", Front Chem, 2018, 4, 00098.

5.  Q. Shen^#, C. Zhang^#, J. Cao, Y. Liu, Y. Liang, M. Zhao, and L. Lai. "De novo design of helical peptides to inhibit TNFα by disrupting its trimer formation", MedChemComm, 2016, 7, 725-729.

4.  C. Zhu, C. Zhang, T. Zhang, X. Zhang, Q. Shen, B. Tang, H. Liang, and L. Lai, "Rational design of TNFα binding proteins based on the de novo designed protein DS119", Protein Sci, 2016, 25(11), 2066-2075.

3.  Q. Shen^#, J. Chen^#, Q. Wang, X. Deng, and L. Lai. "Discovery of highly potent TNFα inhibitors using virtual screening", Eur J Med Chem, 2014, 65, 119-126.

2.  H. Chen, Y. Zhao, H. Li, D. Zhang, Y. Huang, Q. Shen, R. Duyne, F. Kashanchi, C. Zeng, and S. Liu. "Break CDK2/cyclin E1 interface allosterically with small peptides", PLoS One, 2014, 9, e109154.

1.  C. Zhang^#, Q. Shen^#, B. Tang, and L. Lai. "Computational design of helical peptides targeting TNFα", Angew Chem Int Edit, 2013, 52, 11059-1106.

共同一作（#），通讯作者（_*）

2023年，罗伯特德克斯分子编程奖，国际纳米科学、计算和工程学会

2023年，国家高层次青年人才计划

长期招收来自生物、化学、医学、生物医学工程、计算机等跨学科领域的本科生、研究生和博士后，欢迎有志于从事高水平创新研究的同学加入！