易游娱乐

 

葛瑶长聘教轨副教授

电子邮件:[email protected]
通讯地址:上海市东川路800号易游娱乐官网

  • 教育背景

    2013年9月 至 2018年6月  中国科学院上海有机化学研究所, 博士,导师: 丁奎岭研究员


  • 工作经历

    2025年10月-至今 易游娱乐官网-易游娱乐EASYGAME 长聘教轨副教授

    2024年11月-2025年10月 美国芝加哥大学, 化学系, 博士后, 合作导师:何川教授

    2023年01月-2024年10月 美国芝加哥大学, 化学系, 博士后, 合作导师:董广彬教授

    2019年07月-2023年01月 德国莱布尼茨催化研究所, 博士后, 合作导师:Matthias Beller教授

    2018年07月-2019年06月 中国科学院上海有机化学研究所,助理研究员  合作导师:丁奎岭研究员


  • 研究方向

    课题组围绕有机合成与化学生物学交叉,开展以下方向:

    新型催化体系与反应方法学(过渡金属催化、光催化);

    新型含硼有机分子的设计合成与应用;

    核酸及其化学修饰的纯化学检测新策略;

    面向致病蛋白的双官能化小分子开发;

    RNA 新靶点探索与小分子靶向 RNA 研究


  • 代表性论文专著

    1. Yao Ge, Qi Zhu, Yongqi Zhu, Guangbin Dong*. Core diversification using 1,2-oxaborines as a versatile molecular platform. Nat. Chem. 2025 10.1038/s41557-025-01971-0 (ASAP).

    2. Yao Ge, Weiheng Huang, Sebastian Ahrens, Anke Spannenberg, Ralf Jackstell, Matthias Beller*. Synthesis of non-equivalent diamides and amido-esters via Pd-catalysed carbonylation. Nat. Synth. 2024. 3, 202-213.

    (Highlighted as news & views by José Zgheib & Bruce A. Arndtsen, Nat. Synth. 2024, 3, 148-149).

    3. Yao Ge, Fei Ye, Ji Yang, Anke Spannenberg, Haijun Jiao, Ralf Jackstell*, Matthias Beller*. Palladium-catalyzed cascade carbonylation to α,β-unsaturated piperidones via selective cleavage of carbon-carbon triple bonds. Angew. Chem. Int. Ed. 2021, 60, 22393-22400.

    (Hot Paper).

    4. Yao Ge#, Fei Ye#, Ji Yang, Anke Spannenberg, Ralf Jackstell*, Matthias Beller*. Palladium-catalyzed domino aminocarbonylation of alkynols: Direct and selective synthesis of itaconimides. JACS Au. 2021, 1, 1257-1265.

    5. Yao Ge#, Fei Ye#, Jiawang Liu, Ji Yang, Anke Spannenberg, Haijun Jiao, Ralf Jackstell, Matthias Beller*. Ligand-controlled palladium-catalyzed carbonylation of alkynols: Highly selective synthesis of α-methylene-β-lactones. Angew. Chem. Int. Ed. 2020, 59, 21585-21590.

    6. Yao Ge, Zhaobin Han*, Zheng Wang, Kuiling Ding*. Ir-catalyzed double asymmetric hydrogenation of 3,6-dialkylidene-2,5-diketopiperazines for enantioselective synthesis of cyclic dipeptides. J. Am. Chem. Soc. 2019, 141, 8981-8988. 

    (Highlighted by Synthfacts, 2019, 15, 1105).

    7. Yao Ge, Zhaobin Han*, Zheng Wang, Chenguo Feng, Qian Zhao, Guoqiang Lin, Kuiling Ding*. Ir-SpinPHOX catalyzed enantioselective hydrogenation of 3-ylidenephthalides. Angew. Chem. Int. Ed. 2018, 57, 13140-13144.

    (Highlighted by Synthfacts, 2018, 14, 1149).

    8. Yao Ge, Zheng Wang, Zhaobin Han*, Kuiling Ding*. Iridium-catalyzed enantioselective hydrogenation of indole and benzofuran derivatives. Chem. Eur. J. 2020, 26,15482-15486.

    9.  Fei Ye#, Yao Ge#, Anke Spannenberg, Helfried Neumann, Liwen Xu, Matthias Beller*. 3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents. Nat. Commun. 2021, 12, 3257. (#Co-first author).

    10. Fei Ye#, Yao Ge#, Anke Spannenberg, Helfried Neumann, Matthias Beller*. The role of allyl ammonium salts in palladium-catalyzed cascade reactions towards the synthesis of spiro-fused heterocycles. Nat. Commun. 2020, 11, 5383. (#Co-first author). 

    11. Ji Yang#, Jiawang Liu#, Yao Ge, Weiheng Huang, Ferretti Francesco, Helfried Neumann, Haijun Jiao, Robert Franke, Ralf Jackstell, Matthias Beller*. Efficient Palladium-catalyzed carbonylation of 1,3-dienes: Selective synthesis of adipates and other aliphatic diesters. Angew. Chem. Int. Ed. 2021, 60, 9527-9533.

    12. Ji Yang#, Jiawang Liu#, Yao Ge, Weiheng Huang, Helfried Neumann, Ralf Jackstell, Matthias Beller*. Direct and selective synthesis of adipic and otherdicarboxylic acids by Palladium‐catalyzed carbonylation of allylic alcohol. Angew. Chem. Int. Ed. 2020, 59, 20394-20398.

    13. Jiawang Liu#, Zhihong Wei#, Ji Yang#, Yao Ge, Duo Wei, Ralf Jackstell, Haijun Jiao*, Matthias Beller*. Tuning the selectivity of Palladium catalysts for hydroformylation and semihydrogenation of alkynes: Experimental and mechanistic studies. ACS Catal. 2020, 10, 12167-12181.

    14. Ji Yang, Jiawang Liu, Yao Ge, Weiheng Huang, Carolin Schneider, Ricarda Dühren, Robert Franke, Helfried Neumann, Ralf Jackstell, Matthias Beller*. A general platinum-catalyzed alkoxycarbonylation of olefins. Chemical Communications, 2020, 56, 5235-5238.


  • 软件版权登记及专利

    Kuiling Ding, Yao Ge, Zhaobin Han, Zheng Wang. Chinese Patent: CN201810942158.9

    Robert Frank, Matthias Beller, Yao Ge, Peter Kucmierczyk, Helfried Neumann, Germany Patent: EP 23170052.7. Process for alkoxycarbonylation of olefins using synthesis gas.

     


  • 荣誉奖励

    2024  国家海外高层次引进人才计划

    2024 上海市海外高层次人才引进计划


  • 人才需求

    我们欢迎具备有机化学、化学生物学、分子生物学、生物信息学等相关背景的候选人,特别鼓励在金属有机化学、光催化、有机硼化学、理论与计算有机化学、高通量测序、表观组学/蛋白质组学与生信分析方面有训练者应聘。欢迎有志于从事科学研究的同仁加入!


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